Synthesis & Biological Evaluation of Valine Derivatives

During the era of 1935-1945 the sulfonamide provided exceptional advances in the control of infectious diseases, particularly for these three major diseases hemolytic streptococcal infections, gonorrhea and other like pneumococcal pneumonia and meningitis etc. They also proved effective in urinary tract infections. As a therapeutic agent sulfonamides were succeeded as an antibiotic. After this it showed broad control of such infection like tuberculosis, staphylococcal sepsis, rickettsia disease, and infections due to other gram negative bacteria.