Toll-like Receptors in Diseases of the Lung

This book is a review on current understanding of the role of toll-like receptors (TLRs) in the lung on health and disease. Topics covered include 1) the expression, function and activation of TLRs during bacterial, viral and fungal infection of the airways, 2) the role of TLRs in the pathogenesis of genetic and environmental pulmonary disorders, and 3) TLR biology during lung cancer, lung injury and transplantation. Each chapter highlights recent advances in a selected domain in lung disease research. This book serves as a comprehensive resource for both scientists and clinicians studying innate immune mechanisms in the lung and provides a single reference comprising both basic and specialized information. Contents: 1. The Toll-Like Receptor Family 2. TLRs in the Lung in Health and Disease 3. Role of Toll-Like Receptors in Asthma 4. TLRs and the Airway Epithelium in the Cystic Fibrosis Lung 5. COPD: Contribution of TLRs to Disease Pathogenesis 6. Pulmonary Mycobacterial Infections and TLRs 7. Bacterial Infections and Pneumonia: What is the Role of Toll Like Receptors? 8. TLRs and Viral Infection in the Lung 9. Toll-Like Receptor Recognition of Fungal Pathogens in the Lung 10. The Role of Toll-Like Receptors in Lung Transplantation