Assembly of the Vasculature and Its Regulation

Description for Sales People: This is the first comprehensive treatise that deals with the formation of blood vessels during embryonic development. Assembly of the Vasculature and its Regulation presents the most current understanding of vascular angiogenesis and vasculogenesis at the molecular scale. Addressed are recent discoveries in growth factors, adhesion molecules, extracellular components, signaling pathways, and smooth muscle differentiation, beginning with molecular mechanisms and broadening to the development of major organs. The book is an important reference work for all students and researchers working in vascular biology. Table of Contents: Preface by Robert J. Tomanek * Werner Risau 1953-1998 by Georg Breier and Ingo Flamme * The Development of Blood Vessels: Cellular and Molecular Mechanisms by Peter Carmeliet * The Role of Vascular Endothelial Growth Factors and their Receptors during Embryonic Vascular Development by Ingo Flamme and Georg Breier * The Ties that Bind: Emerging Concepts About the Structure and Function of Angiopoietins and their Receptors in Angiogenesis by Chitra Suri and George D. Yancopoulos * Extracellular Matrix in the Regulation of Angiogenesis by Jingsong Xu and Peter Brooks * The Role of Cell Adhesion Receptors in Vascular Development: An Overview by Paul Robson, Susan Pichla, Bin Zhou, H. Scott Baldwin * Development and Differentiation of Vascular Smooth Muscle by Mark W. Majesky, Xiu-Rong Dong, Po-Tsan Ku * Vascular Development of the Heart by Robert J. Tomanek, Xinping Yue, Wei Zheng * Vascular Development of Brain and Spinal Cord by Haymo Kurz and Bodo Christ * Vascular Development of the Kidney by R. Ariel Gomez, Maria L. S. Sequeira Lopez * Vascular Development of the Lung by Daphne E. deMello, Lynne M. Reid * Vascularization of the Placenta by Ronald J. Torry, Joanna Schwartz, Donald S. Torry * IndexPublisher Marketing: The overall scope of this new series will be to evolve an understanding of the genetic basis of (1) how early mesoderm commits to cells of a heart lineage that progressively and irreversibly assemble into a segmented, primary heart tube that can be remodeled into a four-chambered organ, and (2) how blood vessels are derived and assembled both in the heart and in the body. Our central aim is to establish a four-dimensional, spatiotemporal foundation for the heart and blood vessels that can be genetically dissected for function and mechanism. Since Robert DeHaan's seminal chapter "Morphogenesis of the Vertebrate Heart" published in Organogenesis (Holt Rinehart & Winston, NY) in 1965, there have been surprisingly few books devoted to the subject of cardiovascular mor phogenesis, despite the enormous growth of interest that occurred nationally and internationally. Most writings on the subject have been scholarly compilations of the proceedings of major national or international symposia or multiauthored volumes, often without a specific theme. What is missing are the unifying concepts that can make sense out of a burgeoning database of facts. The Editorial Board of this new series believes the time has come for a book series dedicated to cardio vascular morphogenesis that will serve not only as an important archival and didac tic reference source for those who have recently come into the field but also as a guide to the evolution of afield that is clearly coming of age."